SZABMU AHS 2026 Blood Free Quiz 8

1. What triggers sickling in sickle cell anemia?

A. Mutations in alpha chains B. Polymerization of HbS C. Reduced 2,3-BPG D. Increased EPO

2. What is the mechanism of hydroxyurea in sickle cell disease?

A. Decrease HbF B. Increase HbF C. Increase HbS D. Reduce RBC production

3. Which Rh antigen is the most clinically significant?

A. D antigen B. C antigen C. E antigen D. c antigen

4. Which type of incompatibility is most often associated with severe hemolytic disease of the newborn?

A. ABO incompatibility B. Rh incompatibility C. Kell incompatibility D. Duffy incompatibility

5. What is RhoGAM?

A. Vaccine B. Anti-D immunoglobulin C. Antibiotics D. Corticosteroids

6. Which immunoglobulin class crosses the placenta?

A. IgA B. IgM C. IgD D. IgG

7. Which test detects in vivo sensitization of RBCs?

A. Direct antiglobulin test (DAT) B. Indirect antiglobulin test (IAT) C. Coombs test D. Cross-match

8. What does the indirect Coombs test detect?

A. Detects RBC-bound antibodies B. Detects circulating antibodies in serum C. Detects complement D. Detects antigens

9. Which platelet receptors are involved in initial adhesion to von Willebrand factor and collagen?

A. GPIb-IX-V (vWF receptor) B. GPVI (collagen receptor) C. Both GPIb-IX-V and GPVI D. αIIbβ3 (fibrinogen receptor)

10. What is the role of the αIIbβ3 integrin on platelets?

A. Adhesion to collagen B. Fibrinogen binding and aggregation C. Secretion of ADP D. Procoagulant activity